The Effects of Simulated Microgravity on Serum Levels of VEGF in Male Wistar Rats

Nikbakht, Vahid; Kazemi, Ali; Hajebrahimi, Zahra; Khaledi, Neda; Asadi Golzar, Mohammad

Document Type : Research Paper

Authors

¹ Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University.Tehran.IRAN

² Assistant Professor, physical education and sport science faculty, Kharazmi University, Tehran, Iran

³ Aerospace Research Institute, Ministry of Science, Research and Technology, Tehran, Iran

⁴ MSc student of exercise physiology, physical education and sport science faculty, Kharazmi University, Tehran, Iran

Abstract

Endothelial cells differently respond to microgravity condition. The evolution of these responses leads to a more clear understanding of cardiovascular diseases in both gravity and micro-gravity conditions. The aim of this study was to investigate the effects of microgravity condition on serum levels of vascular endothelial growth factor as a motivator for angiogenesis and vasculogenesis processes. A total of 20 rats were randomly divided into two groups including control group and suspension group. The results showed that the VEGF levels of suspension group were higher than control group but it was not significant (P> 0.05). It seems that the hindlimb suspension model used for stimulating microgravity condition does not affect the VEGF in serum levels in male Wistar rats. This may be the result of the body's adaptive response after six weeks. Another probable reason is that VEGF does not play an effective role in cardiovascular changes in microgravity condition. Also the influences of other factor may affect the results.

Keywords

References

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Space Science and Technology

The Effects of Simulated Microgravity on Serum Levels of VEGF in Male Wistar Rats

References

References

Volume 9, Issue 4 - Serial Number 29
Vol. 9, No. 4, Winter 2017
April 2017
Pages 63-68

The Effects of Simulated Microgravity on Serum Levels of VEGF in Male Wistar Rats

References

References

Volume 9, Issue 4 - Serial Number 29Vol. 9, No. 4, Winter 2017April 2017Pages 63-68

Volume 9, Issue 4 - Serial Number 29
Vol. 9, No. 4, Winter 2017
April 2017
Pages 63-68